Photochromic Dithenylethenes: From Sunglasses to the Controlled Release of Drugs

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dc.contributor.author Cai, James (Jianxin)
dc.contributor.author Murphy, Scott
dc.date.accessioned 2011-04-13T19:50:42Z
dc.date.available 2011-04-13T19:50:42Z
dc.date.issued 2011-04-01
dc.identifier.uri http://hdl.handle.net/10294/3276
dc.description.abstract There are several classes of molecules in organic chemistry that exhibit photochromism, one of which is dithienylenthenes (DTEs). Photochromism is defined as a light-induced reversible transformation between two isomeric compounds. Upon irradiation with ultraviolet light, DTEs undergo a change in colour from colourless open-ring isomers to blue colored closed-ring isomers. This colour change is due to the extensive change in molecular geometry between their isomeric forms. The new DTE compounds that I have synthesized will be used to develop drug delivery vehicles that will release their drug cargo upon irradiation with light. Our DTEs will act as the ON/OFF switch for this delivery. These vehicles are prepared by incorporating our DTEs into the membrane of biocompatible lipid vesicles or liposomes, which are spherical, self-closed structures, composed of curved lipid bilayers which entrap part of the solvent, in which they freely float, into their interior. I have developed a new approach for the synthesis of symmetrical and asymmetrical DTE compounds. I will discuss these results and the recent synthesis of dimeric DTE molecules that will also be used in light-activated drug delivery therapies. en_US
dc.language.iso en en_US
dc.publisher University of Regina Graduate Students' Association en_US
dc.relation.ispartofseries Session 1.5 en_US
dc.subject Photochromism en_US
dc.subject Diethenylethenes en_US
dc.subject Synthesis en_US
dc.title Photochromic Dithenylethenes: From Sunglasses to the Controlled Release of Drugs en_US
dc.type Presentation en_US
dc.description.authorstatus Student en_US
dc.description.peerreview yes en_US


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