This qualitative study explores Indigenous experiences of interprofessional collaboration in health settings within Saskatchewan. The study adopts a transformative phenomenological approach, using a critical theory perspective, to generate rich descriptions of the experiences of five Indigenous professionals in multidisciplinary practice. Data was collected through interviews with each participant and a reflective journal and field notes completed by the researcher. Study findings highlight Indigenous ways of knowing; multiple meanings of the term professional; dynamics of power and status; relationships required for collaboration; policy and program factors impacting collaboration; and the suggestions offered by study participants to create a way forward. This study contributes to current research by developing the essence of Indigenous understandings of interactional, organizational, and systemic environments that augment and impede interprofessional collaboration.