Autoregulation is defined as a systematic approach of incorporating individualization into a periodized strength training plan to allow progression towards maximal performance. Recent literature in the areas of velocity-based training (VBT) and the use of rating of perceived exertion (RPE), based on repetitions in reserve (RIR), have become integral components of individualizing strength training programs. The primary purposes of this study were: 1) to examine the accuracy of intra-set RPE across multiple sets to volitional fatigue at 80% 1- repetition maximum (1-RM) in the front squat and high-handle hexagonal bar deadlift (HHBD) and, 2) to determine the relationship between average concentric velocity (ACV) and RPE in the front squat and HHBD in trained males and females (defined as those being able to front squat 1.5x their body mass and HHBD 2x their body mass). Participants performed four sets to volitional fatigue for both the front squat and HHBD at 80% 1-RM. During each set, participants verbally indicated when they believed they were at “6” and “9” on the RPE scale. Results showed that an RPE of “9” was significantly more accurate than an RPE of “6” for the front squat (males: 0.09 versus 0.71, p < 0.001; females: 0.19 versus 0.86, p < 0 .001) and HHBD (males: 0.25 versus 1.00, p = 0.004; females: 0.21 versus 1.19, p < 0.001). A very strong inverse relationship between ACV and RPE was also found in the front squat (r = -0.98) and the HHBD (r = -1.00). These results may have application for using the RPE scale with a higher degree of accuracy based on ACV for program training progression.